In addition, the infusion of IGF-1 can improve angiotensin II-caused myocardial fibrosis via the regulation of the Akt pathway and downregulation of α-SMA expression mediated by ho-associated coiled-coil containing kinases (ROCK)2, leading to the suppression of fibroblast differentiation and proliferation [112]. The gene discussed is ACTA1; the disease is Myocardial fibrosis.