Finally, a recent in vivo and ex vivo study found that CTRP9 (C1q/tumor necrosis factor-related protein-9), a secreted glycoprotein highly expressed in the heart, can also be effective in reducing arterial inflammation and fibrosis, possibly via its inhibitory effects on TGF-β and collagen deposition, in the early phase of MI. This evidence concerns the gene TGFB1 and myocardial infarction.