IL7 and neoplasm: However, making the same sequential sample comparisons at the automatic cut off rank, hypermethylation of the interleukin-7 (IL-7) signaling pathway and response to IL-7 are also indicated in GBMrec, suggesting that suppression (higher methylation) of the IL-7-driven T cell maturation and response may be part of the tumor’s progressive immune evasion or the result of a therapeutic immune suppression.