Therefore, we looked into the RRBS-based sequence data of 112 primary and recurrent GBM pairs from the study by Klughammer et al. [16] and statistically tested the differential CpG methylation in the IL-7 and IL-7Rα promoter + gene regions in individual samples (https://www.ebi.ac.uk/ena, Primary Accession: PRJNA391429; EGAS00001002538, accessed on 17 June 2022) [14]. This evidence concerns the gene IL7R and glioblastoma.