UMOD and chronic kidney disease: SNPs located in the promoter region of UMOD genes, such as rs12917707, rs1333326, and rs4293393, are associated with hypertension risks and chronic kidney diseases (CKD), which is indicative of being related to higher renal uromodulin expression, urinary secretion, altered eGFR, and impaired renal function [156,157,158,159,160,161].