The symptoms of HLH are driven by aberrantly high concentrations of inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-10, IL-12, IL-16, IL-18, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, which result in the activation of dendritic cells, macrophages, NK cells, and CD8+ T cells [9]. The gene discussed is TNF; the disease is hemophagocytic syndrome.