The amplification of PDL1 and PDL2 on tumor cells, coded on chromosome 9p24.1, is mediated by PIM serine/threonine kinases on tumor cells via the constitutive activation of the NFkB and JAK-STAT signaling pathways [49], indicating that NFkB contributes to the immune escape of HRS cells. This evidence concerns the gene PDCD1LG2 and neoplasm.