NFKB1 and neoplasm: The tumor cells that drive this neoplasia, namely, Hodgkin and Reed-Sternberg (HRS) cells, display hallmark features that include their rareness in contrast with an extensive and rich reactive microenvironment, their loss of B-cell phenotype markers, their immune escape capacity and the activation of several key biological pathways, including the JAK/STAT signaling, MAPK/ERK and NFK-B pathways [3,4].