CDKN1B and colorectal carcinoma: It is possible that during the early stages of carcinogenesis, upregulation of miR-200b has a role in proliferation by inhibiting CDKN1B, while later, during the progression of CRC from pT3 to pT4a, downregulation of miR-200b promotes invasiveness and migration, i.e., serosal membrane invasion by targeting other yet unidentified genes.