CD96 and malignant colon neoplasm: In order to test whether anti-CD96 (alone or in combination) can also reduce tumor growth in a mouse colon cancer model, we treated C57BL/6 mice bearing a syngeneic subcutaneous MC-38 tumor (MC-38 mice) in a tumor therapy study twice a week as indicated (Figure 1), with anti-PD-1, anti-CD96, a combination of both antibodies, or isotype controls.