Although it is not possible to causally correlate the currently assessed greater Pg abundance with ASCVD occurrence, one may speculate that the concomitant presence of abundant odontopathogenic strains, such as Pg, if present for years, may have contributed to a further increase in ASCVD risk in subjects with HeFH, which is, per se, a very high-risk, lifelong condition. This evidence concerns the gene JUP and atherosclerosis.