Thus, in this study, we addressed the question of whether oral dysbiosis, namely, the altered abundance of Pg and Fn, was correlated with previous ASCVD (acute myocardial infarction (MI) and/or percutaneous coronary intervention (PCI)/drug-eluting stent (DES) or coronary artery bypass graft (CABG), carotid thromboendarterectomy (CEA)), in high-/very high-risk CVD patients, with or without HeFH. This evidence concerns the gene FN1 and myocardial infarction.