XPO1 is frequently overexpressed and deregulated in various human cancer entities (e.g., in sarcoma, DLBCL, multiple myeloma, KRAS-mutant lung cancer, pancreatic, ovarian, glioma, lung, gastric, prostate, and colorectal cancers) and is associated with poor prognosis [42,43,44]. The gene discussed is XPO1; the disease is AL amyloidosis.