CDKN1A and glioblastoma: Accordingly, GBM cells were treated with 100 nM Eltanexor for 24 h, GSC 74 cells were treated with the identical concentration for 48 h, and the mRNA expression levels of TP53, BAX1, Tp53AIP1, Tp53i3, BBC3, PMAIP1, CDKN1A (p21), PIDD1, and PML were determined by qPCR (Figure 3).