Simultaneously created four oncolytic HSV-1 vectors, which express murine soluble B7.1 (vHsv-B7.1-Ig), murine IL-12 (vHsv-IL-12), murine IL-18 (vHsv-IL-18), and no transgene, were tested in A/J mice harbouring s.c. tumours of syngeneic and poorly immunogenic Neuro2a neuroblastoma. Here, CD80 is linked to neoplasm.