Expression of IL-12, IL-15, IL-7, CCL19, PD-1v plus GM-CSF. The anti-tumour efficacy of HSV-2 vectors engineered to express IL-12, IL-15, PD-1v, GM-CSF, and IL-7 - CCL19 were evaluated in syngeneic CT26 tumour-bearing and 4T1 tumour-bearing mice [221]. This evidence concerns the gene CSF2 and neoplasm.