CSF2 and pancreatic neoplasm: Relaxin plus GM-CSF and IL-12. The antitumor efficacy by a combination of oncolytic adenovirus (oAd/IL12/ GM-RLX), which co-expresses relaxin (RLX), IL-12 (IL-12p35 and IL-12p40), and GM-CSF in combination with anti-PD-1 was examined in hamster s.c. and orthotopic pancreatic tumour models [218].