VEGF binding short hairpin RNA plus IL-12. To overcome tumour-mediated immunosuppression and enhance the potency of immune gene therapy, oncolytic adenovirus (Ad) co-expressing IL-12 and VEGF-specific short hairpin ribonucleic acid (shVEGF; RdB/IL12/shVEGF) was evaluated [219]. This evidence concerns the gene VEGFA and neoplasm.