CSF2 and neoplasm: Interestingly, in one study it was reported that an oncolytic HSV vector armed with IL-12, showed better efficacy than a GM-CSF armed vector of the same backbone in certain tumour-bearing mice models [237], but in the study of Hu et al., oHSV-2 encoding GM-CSF showed opposite better efficacy than IL-12 armed vector of the same backbone [221].