PTPN11 and Sepsis: Non-signaling functions have also been described for SHP2: SHP2 can translocate to the mitochondria following sepsis in cardiomyocytes or upon NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in macrophages, where it dephosphorylates adenine nucleotide translocase 1 (ANT1) or components of the Oxidative Phosphorylation (OXPHOS) complex [19,20,21], thereby regulating mitochondria activity.