The overexpression of miRNA-18a-5p has been identified as pro-atherogenic miRNA as it promotes proliferation and migration of vascular smooth muscle cells [25,26]; moreover, an animal model of oxygen-induced proliferative retinopathy revealed that the overexpression of miR-18a-5p in human retinal microvascular endothelial cell, was anti-angiogenic as inhibited angiogenesis via significant downregulation of fibroblast growth factor-1 and hypoxia-inducible factor-1 alpha (HIF-1α), which are both closely associated with angiogenesis [27]. Here, HIF1A is linked to retinal disorder.