By inputting hsa-miR-18a-5p, IL-10, CRP, VEGF-D, thrombomodulin, along with glucose to demonstrate a diabetic state into IPA software, miR-18a-5p was predicted to enhance the progression of atherosclerosis, infarction, and inflammatory response whilst inhibiting angiogenesis and blood coagulation. The gene discussed is THBD; the disease is atherosclerosis.