HIF1A and myocardial infarction: The overexpression of HIF-1α in mesenchymal stem cell-derived exosomes on hypoxia-pre-treated HUVECs demonstrated that the angiogenic function, migratory capacity, and proliferation of the hypoxia-injured cells were reversed by HIF-1α-overexpressed exosomes; moreover, they reported enhanced neovessel formation in the infarcted area of myocardial infarction model, demonstrating the cardio-protective role mediated by HIF-1α [90].