LHX2 and hydrops fetalis: Thus, the ability of postnatal epithelialization in wounds reflects increased skin Wnt/β-catenin activation in the wound bed, increasing the number of fibroblasts that cannot induce HF formation [27]; however, loss of Lhx2 is believed to cause misregulation of the Wnt/βcatenin pathway [28], thereby affecting the formation of scar and follicles.