KRT1 and ichthyosis: Around the same time, Choate et al. demonstrated that each of the multiple healthy ‘confetti-like’ spots in patients with ichthyosis with confetti (IWC) due to germline variants in KRT10 (IWC-I) or KRT1 (IWC-II) represent a separate occurrence of RM in a single keratinocyte clone [80,81].