COVID-19 is associated with abnormal levels of pro-inflammatory cytokines and chemokines such as IFN-γ, TNF-α, TGF, IL1, IL2, IL6, IL10, IL12, M-CSF, G-CSF, GM-CSF, IP-10, MCP-1, MIP 1, vascular endothelial growth factor (VEGF), RANTES, and many others. The gene discussed is TNF; the disease is COVID-19.