In addition, tumor cells in chronic inflammation secrete cytokines (transforming growth factor (TGF)-β and interleukin (IL)-10) and chemokines to prevent dendritic cells (DCs) from the presentation of tumor antigens, and to recruit immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), regulatory T cells, and M2 macrophages, thereby resulting in the generation of a cancer-promoting inflammation environment by suppressing anti-tumor immune responses [8]. Here, IL10 is linked to neoplasm.