In osteosarcoma, for instance, miR-29s were shown to be an oncogenic factor where their downregulation resulted in significantly reduced cell growth and colony formation of osteosarcoma MG-63 cells, probably via miR-29/TGF-β1/PUMA (p53 upregulated modulator of apoptosis) axis [62]. This evidence concerns the gene TGFB1 and osteosarcoma.