CDK6 and cancer: Furthermore, miR-29s could act as pro-apoptotic, anti-proliferative, anti-metastatic/EMT, and immunomodulatory factors by directly binding to 3′-UTR of the target genes such as myeloid cell leukemia 1 (MCL1) [30], cyclin-dependent kinase 6 (CDK6) [31], cell division cycle 42 (CDC42) [32] and matrix metalloproteinase 2 (MMP2) [17] in human cancers.