TLR3 and hepatocellular carcinoma: It was indicated that TLR3 (Toll-like receptor 3) activated macrophages produced exosomes containing miRNA-29s that were proved to be able to prevent hepatitis C virus (HCV) replication in HCC cell line, suggesting the potential use of exosomes comprising miR-29 family members as a therapy to control HCV replication in infected hepatocytes [89].