In the study by Hirahara et al., serum levels of IFN-γ, TNF-α, IL-6, and IL-10 in patients with SJS/TEN were decreased after 4 days of methylprednisolone pulse therapy compared with pre-administration levels; however, statistically significant decrease was observed only in IFN-γ and IL-6 levels [52]. This evidence concerns the gene IL6 and toxic epidermal necrolysis.