For example, breakpoint cluster region-Abelson (BCR-ABL) tyrosine kinase and EGFR are overexpressed in imatinib-resistant chronic myeloid leukemia (CML) and crizotinib-resistant anaplastic lymphoma kinase (ALK)-positive NSCLC, respectively [43,44,45]. This evidence concerns the gene ALK and chronic myelogenous leukemia, BCR-ABL1 positive.