Additionally, many other PROTACs have already been developed or are being developed based on IMiDs recruiting CRBN to target cancer-related proteins, including CDK6, MCL-1/BCL-2, BCL-xL, HDAC6, BTK, BRAF, FKBP12, PARP1, BCR-ABL, FAK, and PD-L1 [66,67,69,87,88,89]. This evidence concerns the gene BTK and cancer.