A decrease in the number of insulin receptors in the brains of elderly patients with Alzheimer’s disease along with a decrease in mRNA expression were observed, producing deviations in the insulin receptor–IRS1–AKT–mTOR signal pathway and its various serine kinases, giving rise to amyloid-β and tau protein lesions [6]. The gene discussed is INSR; the disease is early-onset autosomal dominant Alzheimer disease.