Within the epigenetics of AD, several genes are hypermethylated (APOE, MTHFR, MAPT, SORB3), and others are related to the production of the Aβ peptide (PSEN1, APP, PP2A, CREB5, S100A2, BACE) and remain hypomethylated. The gene discussed is APP; the disease is Alzheimer disease.