Arachidonic acid (AA) is metabolized by cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) enzymes to form pro-inflammatory molecules, such as prostaglandin E2 (PGE2), a COX-2 product involved in the development of AD through its EP receptors [75,76]. This evidence concerns the gene PTGS2 and Alzheimer disease.