LVEF < 50% was associated with a significantly higher proportion of anti-EPOR antibody positivity (9.7% vs. 3.5%, p = 0.044), male sex (85.5% vs. 67.9%, p = 0.006), DM (64.5% vs. 49.2%, p = 0.036), and IHD (51.6% vs. 21.3%, p < 0.001) compared to LVEF ≥ 50%. Here, EPOR is linked to myocardial ischemia.