Hyperglycemia could directly exacerbate SARS-CoV-2 infection, promoting the expression and activation of, angiotensin-converting enzyme 2 (ACE2) cellular receptor, the main receptor of the SARS-CoV-2, and increasing the expression of the serine protease TMPRSS2, which mediates the cleavage of the viral spike protein [27]. The gene discussed is ACE2; the disease is Hyperglycemia.