As a matter of fact, an increase in DA is related, in turn, not only to improvements in the locomotor function in vivo in the ALS Drosophila model for a TDP-43 proteinopathy [43], but also to a better cognitive status in ALS patients, given the significant decrease in the DA receptors in some areas outside the striatum [44]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.