Nectin-4 blocking Abs stimulates an NK-mediated antitumor response [113]. The participation of nectin-4 in the processes of proliferation, invasion, and metastasis through the activation of Pi3k/Akt and WNT/β-catenin signaling pathways has been shown [114]. The revealed hyperexpression of nectin-4 by tumor tissues is associated with tumor aggressiveness and poor clinical prognosis [115,116]. This evidence concerns the gene AKT1 and neoplasm.