The expression of VSIG-3 by tumor tissues was found in CRC, HCC, and in intestinal-type GC [151]. The overexpression of VSIG-3 is associated with the expression of VISTA, as well as with PD-L1 and PD-1, with a high degree of tumor malignancy, and a poor clinical prognosis in glioblastoma has been revealed [152].Experimental models show the antitumor efficacy of the SG7 Ab, which inhibits VISTA binding to VSIG-3 and PSGL-1 [174]. This evidence concerns the gene SELPLG and hepatocellular carcinoma.