An increased expression of TIM-3 was detected in CD4+ and CD8+ TILs in lung cancer, stomach cancer, head and neck carcinomas, and melanoma [41] in antigen-specific T-cells of peripheral blood of patients with various types of cancer [5] and in tumor-infiltrating DCs compared to DCs in normal tissues [24]. The gene discussed is HAVCR2; the disease is gastric cancer.