In a recent work by Ghouzlani et al. [152], conducted on samples obtained from patients with glioblastomas, it was revealed that the overexpression of VSIG-3 is associated with the expression of VISTA, as well as with PD-L1 and PD-1, with a high degree of tumor malignancy and a poor clinical prognosis. This evidence concerns the gene CD274 and neoplasm.