The restoration of cytolytic functions of CD8+ T- cells in response to the inhibition of galectin-3 was shown, which indicates the role of galectin-3 in the suppression of antitumor immunity. The direct involvement of galectin-3 in the processes of metastasis was revealed [72,73,74], as well as the association of galectin-3 expression with poor clinical prognosis [75]. However, in melanoma and glioblastoma, the presence of galectin-3 is beneficial for patients [76]. The gene discussed is CD8A; the disease is melanoma.