A high level of soluble LSECtin in the blood serum of patients with CRC is associated with the presence of liver metastases [78]. The expression of LSECtin and its interaction with LAG-3 molecules are shown on B16 melanoma cells. It is accompanied by the suppression of the T-cell antitumor response, and the blockade of LSECtin/LAG-3 interaction restores the secretion of IFNγ [79]. This evidence concerns the gene CLEC4G and melanoma.