On the contrary, genotoxic stress induced endothelial dysfunction in HCAEC is mainly associated with the p53, GAS6/AXL, JNK/SAPK, PI3K/AKT, and DNA damage response signaling pathways, inflammatory activation of endothelial cells, inflammatory response regulation, endothelial migration and differentiation, apoptosis, adhesion of mononuclear blood fractions to the plasma membrane of endothelial cells, and oxidative stress response. The gene discussed is MAPK8; the disease is endothelial dysfunction.