BRCA1 and familial pancreatic carcinoma: Of note, the American Society for Gastrointestinal Endoscopy (ASGE) recently recommended not to require family history of PDAC in individuals with BRCA1/2 pathogenic variants to be considered for pancreatic cancer screening, given that almost two in three BRCA1/2-positive individuals with PDAC do not have a positive family history and would have been missed [21].