Additionally, when the treatment and control groups were further evaluated according to their high-sensitivity CRP (hs-CRP) values at entry, with patients categorized as either being in the high hs-CRP group (>0.05 mg/dL) or the low hs-CRP group value (<0.05 mg/dL), it can be concluded that periodontal treatment can significantly reduce HbA1c in the presence of inflammation as assessed by hs-CRP due to periodontitis [10]. This evidence concerns the gene CRP and periodontitis.