The gene-gene interaction network generated by GeneMANIA identified seven genes linked to PJI: mannose binding lectin 2 (MBL2), colony stimulating factor 3 (CSF3), interleukin receptor 1 antagonist (IL1RN), vitamin D receptor (VDR), tumor necrosis factor (TNF), interleukin 6 (IL6), and interleukin 1B (IL1B). This evidence concerns the gene IL6 and juvenile polyposis syndrome.