Indeed, endothelial cell Nox1 is required for hypertension in response to AngII [127], while NOX2 overexpression in endothelial cells further promotes blood pressure elevation in response to AngII [128] and stimulates macrophage recruitment and the initiation of atherosclerotic plaque formation in ApoE−/− mice [129]. Here, NOX1 is linked to hypertensive disorder.