NOS3 and hypertensive disorder: The expression of NOX5 is increased in the coronary arteries of atherosclerosis patients [130], and the endothelial cell-specific expression of human NOX5 in mice results in hypertension with advanced age via the uncoupling of eNOS (Figure 3) and the repression of cyclic GMP (cGMP) signaling [131], indicating maladaptive roles for endothelial NOX5 in cardiovascular disease.