All treatments equally prevented the obesity-induced increase in the adipocyte area (Figure 6; p < 0.05) and in the mRNA levels of MCP-1 (Figure 7A; p < 0.001 for all) and IL-6 (Figure 7C; p < 0.01 for all) in retroperitoneal adipose tissue. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.