DC only attenuated the obesity-induced downregulation of NOX-4 (p < 0.05), whereas DCE also prevented the alterations in the mRNA levels of NOX-4 (p < 0.01), GSR (p < 0.05) and GPX-3 (p < 0.01). The gene discussed is NOX4; the disease is obesity due to melanocortin 4 receptor deficiency.