NOX4 and obesity due to melanocortin 4 receptor deficiency: Finally, DCT attenuated the obesity induced-changes in the gene expression of NOX-1 (p < 0.05), NOX-4 (p < 0.01), and GPX-3 (p < 0.05) and DCTE the changes in NOX-1 and NOX-4 (p < 0.05 for both).