NOX4 and obesity due to melanocortin 4 receptor deficiency: Obesity induced a significant decrease in the mRNA levels of NOX-4 (Figure 9F; p < 0.05), GSR (Figure 9G; p < 0.01), GPX-3 (Figure 9H; p < 0.05), and SOD-1 (Figure 9I; p < 0.05).