Indeed, our results indicate that, opposite to caloric reduction alone, supplementation with carob extract not only reduces the gene expression of certain pro-inflammatory markers, such as MCP-1 or IL-1β in skeletal muscle and hepatic tissues, but also the obesity-induced alterations in the mRNA levels of oxidative stress-related markers. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.