DC attenuated the reduction in the gene expression of GSR and SOD-1 (p < 0.05 for both), whereas DCE, DCT, and DCTE completely prevented the obesity-induced reduction in the mRNA levels of NOX-4, GSR, GPX-3 and SOD-1 (p < 0.05). This evidence concerns the gene NOX4 and obesity due to melanocortin 4 receptor deficiency.