CERKL and retinitis pigmentosa 1: Recently, the central role of OS in the pathogenesis of RP has been underlined by Gallenga et al., who observed that several mutations in endogenous antioxidant pathways such as mutY DNA glycosylase (MUTYH), ceramide-kinase like (CERKL) and glyoxalase 1 (GLO1) are frequently implicated [61].