SIRT1 and chronic obstructive pulmonary disease: Resveratrol, a phytoalexin derived from many plants, is a potent scavenger of free radicals and a regulator of genes involved in endothelial dysfunction, including the gene coding for Sirtuin 1 (Sirt1), a protein deacetylase acting as an oxidative stress sensor and a repressor of inflammatory response [57], whose increase in peripheral blood mononuclear cells (PBMCs) of stable coronary disease patients with chronic obstructive pulmonary disease (COPD) treated with ticagrelor has been linked to the protective effect of this antiplatelet drug against endothelial dysfunction [42].