Many of the molecular pathways involved in endothelial dysfunction are well known, and include, together with the above cited players such as nitric oxide synthase (NO), lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) involved in the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway [60,61], emerging pathways such as those related to loss of function of the protein KRIT1 [62], and the epidermal growth factor receptor (EGFR) [43]. The gene discussed is EGFR; the disease is endothelial dysfunction.