In the present review, we harness the therapeutic potential of nuclear factor E2-related factor 2 (Nrf2), a key transcription factor orchestrating the cell response to OS, and its target gene BTB and CNC homology 1 (Bach1), a transcriptional repressor of Nrf2, which hold great promise in modulating multiple etiological pathways against neuronal cell death in PD. The gene discussed is BACH1; the disease is Parkinson disease.