In most pMCAO and tMCAO animals, the expression of the Nrf2 protein, its downstream antioxidant target genes and its expressed target proteins (heme oxygenase1 (HO-1), NAD(P)H: Quinone oxidoreductase I (NQO1), etc.)were upregulated in different ischemic sites (cortex, hippocampus, etc.)and different ischemic cells (neurons, astrocytes, microglia, etc.)after cerebral ischemia [31,32,33,34,35]. This evidence concerns the gene HMOX1 and brain ischemia.