TB was found to have tumor suppressive effects against multiple cancers, including non-small-cell lung cancer, osteosarcoma, hepatocellular carcinoma, gliomas, and melanoma, through modulating oncogenic pathways, PI3K/Akt, p53/JNK, and NF-κB pathway [15,16,17,18,19,20]. The gene discussed is PIK3CA; the disease is cancer.