PPARA and type 2 diabetes mellitus: The present study, for the first time, discovered that: (1) ICS II, a naturally occurring flavonoids compound, effectively overcomes T2DM; (2) ICS II protected against T2DM due to attenuate oxidative stress and inflammation; (3) The exciting therapeutic effect of ICS II on T2DM might be mediated by targeting PPARα/γ (Figure 11).