TP53 and fetal growth restriction: In agreement with the decreased sirtuin-1 expression, we observed an increased protein expression of acetylated p53 at Lys-382, a target of sirtuin-1 deacetylase, in IUGR male livers, indicating an impaired deacetylation action of sirtuin-1 and an overall reduction in sirtuin-1 activity [30], which could explain the presence of SIPS in IUGR male livers.