Tanshinone IIA has been reported attenuate silica-induced PF via activation of the Nrf2/Trx/TrxR axis and Nrf2-mediated inhibition of NOX4 expression, EMT, and TGF-β1/Smad signaling [113,114,115]. The gene discussed is TGFB1; the disease is pemphigus foliaceus.