Research has shown that polydatin protects against ROS-induced PF and reverses TGF-β1-induced pulmonary epithelial cell EMT in asthma by promoting Nrf2-mediated expression of HO−1 and NQO1 and inhibiting NOX1 and NOX4 expression [130]. The gene discussed is TGFB1; the disease is pemphigus foliaceus.