Under hypoxia (mimicking conditions of placental dysfunction akin to that in preeclampsia), silencing cytotrophoblast OLAH did not alter the expression of the two sFLT1 transcript isoforms, sFLT-e15a (Figure 6A) or sFLT-i13 (Figure 6B), nor secretion of the functional sFLT1 protein (Figure 6C). The gene discussed is OLAH; the disease is preeclampsia.