For instance, a mixture of probiotic strains Bifidobacterium longum CH57 and Lactobacillus brevis CH23 have been proved to ameliorate 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis by inhibiting the expression of M1 macrophages marker IL-1β, TNF-α and increasing the M2 macrophage markers IL-10, Arg-1 and CD204 [34]. The gene discussed is ARG1; the disease is colitis.