UCP1 and obesity due to melanocortin 4 receptor deficiency: This present study expanded and advanced the previous finding by showing that the iBAT UCP1 protein expression from immunofluorescence and Western blot analysis significantly increased at doses of 1 and 10 mg/kg of melatonin and, surprisingly, even at 0.1mg/kg of melatonin in an experimental model of diabetes and obesity.