ACHE and neuroblastoma: The slightly lower-performing piperazine analogue 12d is instead the most interesting Aβ aggregation inhibitor (I% = 60% at 10 μM), as well as a more selective AChE inhibitor (IC50 = 0.599 μM) and shows no cytotoxic effects on neuroblastoma cell lines at 24 h at 100 μM.