Moreover, the multitarget tyrosine kinase inhibitor pazopanib, which blocks vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and c-KIT, in combination with lapatinib, has also been proven in HER2 invasive BC pretreated with chemotherapy and trastuzumab, with a worse or similar PFS (Progression-free survival) compared to lapatinib treatment alone (lapatinib plus placebo) (NCT00558103). The gene discussed is ERBB2; the disease is breast cancer.