BCL2 and cancer: Annomuricin E halted HT-29 cell proliferation, HCT-116 with an IC50 value of 1.62 ± 0.24 μg/mL, 32.51 ± 1.18 μg/mL after 48 h, followed by G1 cell cycle arrest and excessive accumulation of ROS-induced apoptosis in colorectal HT-29 and HCT-116 cancer cells, which was accompanied by MMP degradation, cytochrome c leakage, initiator and executor caspase activation, Bax upregulation, and Bcl-2 protein down-regulation (Figure 6).