TRIM31 was shown to induce p65 translocation to the nucleus, and subsequent phosphorylation of IκBα, leading ultimately to the upregulation of numerous genes involved in tumor proliferation, migration, and invasion, such as BCL2L1, Snail, MYC, MMP9, MMP13, CXCL5, TWIST1, and CCND1. Inhibition of the NF-κB pathway abrogated the effects of TRIM31 overexpression [94]. Here, TRIM31 is linked to neoplasm.