However, several members of the family (TRIM11, TRIM17, TRIM21, TRIM22, TRIM47, TRIM65, TRIM8, TRIM31, TRIM24, TRIM28, TRIM33, TRIM37, TRIM45, TRIM14, TRIM44, and TRIM3) seem to be implicated either as oncogenes or tumor-suppressors in the pathogenesis of gliomas. The gene discussed is TRIM47; the disease is neoplasm.