Furthermore, the pediatric-type diffuse high-grade gliomas include the diffuse midline gliomas with H3 K27-altered, the diffuse hemispheric gliomas with H3 G34-mutant, the diffuse pediatric-type high-grade gliomas with H3-wildtype and IDH-wildtype and the infant-type hemispheric gliomas. The gene discussed is IDH1; the disease is central nervous system cancer.