However, several members of the family (TRIM11, TRIM17, TRIM21, TRIM22, TRIM47, TRIM65, TRIM8, TRIM31, TRIM24, TRIM28, TRIM33, TRIM37, TRIM45, TRIM14, TRIM44, and TRIM3) seem to be implicated either as oncogenes or tumor-suppressors in the pathogenesis of gliomas. This evidence concerns the gene TRIM45 and central nervous system cancer.