However, several members of the family (TRIM11, TRIM17, TRIM21, TRIM22, TRIM47, TRIM65, TRIM8, TRIM31, TRIM24, TRIM28, TRIM33, TRIM37, TRIM45, TRIM14, TRIM44, and TRIM3) seem to be implicated either as oncogenes or tumor-suppressors in the pathogenesis of gliomas. The gene discussed is TRIM65; the disease is central nervous system cancer.