The expression profiles of selected biomarkers determined in OS cell lines were compared with the HeLa cell line, known for its osteoinductive properties mediated by bone morphogenetic proteins (BMPs) [6,7], as well as with human multipotent adipose tissue-derived stromal cells (hASCs), constituting a tumour microenvironment [8], as well as contributing to osteosarcoma progression, metastasis and proliferation [9]. Here, CLN5 is linked to osteosarcoma.