For vinorelbine, EPHA2 codes for EPH receptor A2, a tyrosine kinase involved in cancer-related signaling, while NGEF codes for a guanine nucleotide exchange factor associated with signaling from EPH receptor A2, RhoA, Rac1 and CDC42 as well as cellular transformation and tumorigenesis [46,47]. The gene discussed is CDC42; the disease is cancer.