PKM and breast cancer: Lastly, secretion of SNHG3 from breast cancer associated fibroblasts promotes breast cancer cell proliferation via its action as a sponge for miR-330-5p [89] which inhibits pyruvate kinase M1/M2 (PKM) and miR-384 which inhibits hepatoma derived growth factor (HDGF) and also induces breast cancer cell migration, and invasion [90].