Specifically, regarding breast cancer, it was recently shown that overexpression of Linc00518 in MCF-7 breast cancer cells recruited DNMT on caudal type homeobox 2 (CDX2) gene promoter and its methylation decreased the CDX2 expression leading to activation of the Wnt signaling pathway with accompanying upregulation of β-catenin, c-Myc, CyclinD1, Slug, Snail, Twist, and downregulation of E-cadherin [45], clearly showing promotion of EMT. This evidence concerns the gene TWIST1 and breast cancer.