Similarly, all studied SNHGs are involved in EMT through activation of various athways including Notch-1, but in vivo experiments reveal a more crucial role in tumor growth and metastasis for SNHG1, SNHG3, SNHG5, SNHG12, and SNORA71A (Table 2 and Figure 1). This evidence concerns the gene SNHG3 and neoplasm.