TFAM and breast cancer: Moreover, SNHG1 was upregulated under hypoxic conditions in breast cancer cells MDA-MB-231 in a hypoxia-inducible factor-1 (HIF-1) dependent manner and was found to be co-expressed with miR-199a-3p regulating its target gene transcription factor A mitochondrial (TFAM), ultimately leading to breast cancer cell metastasis [86].