In tumor cells, aberrant activation and cross talk between multiple signal-transduction pathways that might initially be driven by growth factors and sterol hormones, such as PI3K/AKT and MAPK pathways [16,19,20,21,22,23], stimulate the expression and/or nuclear maturation of SREBP, leading to the amplification of FASN irrespective of extracellular lipid levels [16,17]. Here, FASN is linked to neoplasm.