Next, we analyzed the effect of high-risk genetic mutations for the progression of myelodysplastic syndrome to AML [26], that is, wild type SF3B1 or mutations in SRSF2, RUNX1, U2AF1, ASXL1, and TP53, on the survival outcomes in the MF cohort (Figure 4). Here, ASXL1 is linked to myelodysplastic syndrome.